Baseline rCLR panel sum using the standard trimmed denominator.

Usage

score_rclr_baseline(
  expr,
  meta,
  panel,
  trim_upper = 0.1,
  trim_lower = 0.05,
  exclude_features = c("hsa-miR-451a", "hsa-miR-16-5p", "hsa-miR-486-5p",
    "hsa-miR-144-3p", "hsa-miR-223-3p"),
  min_centering_size = 8L,
  pseudocount = NULL
)

Arguments

expr: Numeric matrix, samples x features.
meta: Data frame aligned to `expr`.
panel: Character vector of panel features.
trim_upper, trim_lower: Feature trimming fractions for rCLR denominator selection.
exclude_features: Features excluded from denominator selection.
min_centering_size: Minimum denominator size before fallback.
pseudocount: Optional additive pseudocount before log transform.