Score rCLR after excluding blood-cell-derived miRNAs — score_platelet_exclusion

Removes the nominated platelet/erythrocyte miRNAs from the expression matrix before computing the rCLR denominator and before scoring the panel.

Usage

score_platelet_exclusion_rclr(
  expr,
  meta,
  panel,
  biofluid_col = "biofluid",
  excluded_features = .bfa_default_blood_cell_mirnas(),
  feature_weights = NULL,
  pseudocount = NULL,
  trim_upper = 0.1,
  trim_lower = 0.05,
  min_centering_size = 8L,
  ...
)

Arguments

expr: Numeric matrix, samples x features.
meta: Data frame aligned to `expr`.
panel: Character vector of panel features.
biofluid_col: Biofluid column retained for a common scorer signature.
excluded_features: Features removed before centering and scoring.
feature_weights: Optional named numeric panel weights.
pseudocount: Optional additive pseudocount before log transform.
trim_upper, trim_lower: Feature trimming fractions for rCLR denominator selection.
min_centering_size: Minimum denominator size before fallback.
...: Reserved for scorer-interface compatibility.