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Utilities for simple deployment-facing hemolysis mitigations used in biomarker-panel robustness benchmarks:

  • a Blondal-style proxy pre-filter tuned on training controls only;

  • a weighted centered log-ratio (CLR) transform that down-weights hemolysis-sensitive features while preserving within-sample centering.

The default proxy uses the eLife-14 panel overlap markers `miR-92a-3p / miR-320d` because canonical `miR-23a / miR-451a` are not available in the frozen 14-miRNA panel.