Fit kit-stable denominator anchors on training data only. — fit_kit_stable

Lower kit_variance_ratio means lower between-kit signal relative to within-kit noise. The returned anchor table records the training cohorts and denominator used by downstream scoring. Evaluation data must not be included.

Usage

fit_kit_stable_anchors(
  expr,
  meta,
  kit_col = NULL,
  cohort_col = "cohort",
  anchor_fraction = 0.05,
  min_anchors = 8L,
  min_samples_per_kit = 5L,
  pseudocount = NULL
)

Arguments

expr: Numeric matrix, samples x features.
meta: Data frame aligned to `expr`.
kit_col: Optional kit column. When NULL, a kit-like column is inferred.
cohort_col: Column identifying training cohorts.
anchor_fraction: Fraction of eligible features selected as anchors.
min_anchors: Minimum number of anchors to select.
min_samples_per_kit: Minimum samples per kit stratum.
pseudocount: Optional additive pseudocount before log transform.