Convert qPCR Ct values to relative abundance with a fitted DA-cVAE's frozen reference

Applies a fitted ct-mode fit_dacvae model's FROZEN per-miRNA Ct reference (median train Ct), assay efficiency \(E\), and censored-Ct MZR floor to a matrix of qPCR cycle-threshold values, returning the relative-abundance matrix \(E^{-(Ct - \mathrm{ref})}\) (censored / undetected Ct \(\to\) the floor). Exposed for the cross-platform harness to convert qPCR cohorts to the abundance simplex with the SAME frozen reference the model was fit under (single-sample-faithful). For an abundance-mode model this is a no-op identity.

Usage

dacvae_ct_to_abundance(model, X)

Arguments

model

A dacvae_model from fit_dacvae.

X

Numeric matrix of qPCR Ct values (samples x features); named feature columns.

Value

Relative-abundance matrix with the same dimensions/dimnames as X.

See also

fit_dacvae, score_dacvae