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Implements centered log-ratio (CLR) transforms and dense neural-network classifiers for within-sample biomarker panel classification. On log-scale inputs the CLR transform is a simple within-sample centering operation, making it invariant to uniform additive shifts applied to all features of a sample.

References

Aitchison J. (1986). The Statistical Analysis of Compositional Data. Chapman and Hall.

Egozcue JJ, Pawlowsky-Glahn V, Mateu-Figueras G, Barcelo-Vidal C. (2003). Isometric logratio transformations for compositional data analysis. Mathematical Geology, 35(3), 279-300.

Gloor GB, Macklaim JM, Pawlowsky-Glahn V, Egozcue JJ. (2017). Microbiome datasets are compositional: and this is not optional. Frontiers in Microbiology, 8, 2224.

Quinn TP, Erb I, Richardson MF, Crowley TM. (2020). Understanding sequencing data as compositions: an outlook and review. Bioinformatics, 36(16), 4424-4432.